4-(1-(Methoxycarbonyl)cyclopropyl)phenylboronic acid
(4-(1-(Methoxycarbonyl)cyclopropyl)-phenyl)boronic acid
CAS: 1217501-08-0
Molecular Formula: C11H13BO4
4-(1-(Methoxycarbonyl)cyclopropyl)phenylboronic acid - Names and Identifiers
4-(1-(Methoxycarbonyl)cyclopropyl)phenylboronic acid - Physico-chemical Properties
| Molecular Formula | C11H13BO4 |
| Molar Mass | 220.03 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | IRRITANT |
| MDL | MFCD12546570 |
4-(1-(Methoxycarbonyl)cyclopropyl)phenylboronic acid - Introduction
(4-(1-(Methoxycarbonyl)cyclopropyl)-phenyl)boronic acid is an organic boron compound whose chemical formula is C10H11BO4. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White crystalline solid
-Melting Point: 148-150°C
-Molecular weight: 210.01g/mol
-Solubility: Soluble in some organic solvents, such as ethanol and dimethyl ether
Use:
- (4-(1-(Methoxycarbonyl)cyclopropyl)-phenyl)boronic acid is a commonly used reagent in organic synthesis and is used to synthesize other organic compounds.
-It can be used as a stable ligand for aromatic hydrocarbon lithium or magnesium reagents for metal organic chemical reactions.
-It can also be used to catalyze coupling reactions, such as Suzuki coupling reactions and Suzuki-Miyaura cross-coupling reactions, to construct carbon-carbon bonds.
Preparation Method:
The preparation of (4-(1-(Methoxycarbonyl)cyclopropyl)-phenyl)boronic acid can be carried out by the following steps:
1. 1-Bromocyclopropane is reacted with methyl formate to obtain methyl (1-(methoxycarbonyl) cyclopropyl) formate.
2. The product obtained in step 1 is reacted with phenylboronic acid in acetonitrile or dimethylformamide to produce the target product.
Safety Information:
(4-(1-(Methoxycarbonyl)cyclopropyl)-phenyl) The safety information of boronic acid is limited, so the following safety measures should be followed when using it:
-It may be irritating to the eyes, skin and respiratory tract, so avoid contact, if contact occurs, rinse immediately with plenty of water.
-Follow good laboratory safety practices during handling and storage.
-Keep away from fire and heat sources and store in a dry, cool place.
-Wear appropriate protective gloves, glasses and protective clothing during use or handling. If ingested or inhaled, seek medical attention immediately.
Nature:
-Appearance: White crystalline solid
-Melting Point: 148-150°C
-Molecular weight: 210.01g/mol
-Solubility: Soluble in some organic solvents, such as ethanol and dimethyl ether
Use:
- (4-(1-(Methoxycarbonyl)cyclopropyl)-phenyl)boronic acid is a commonly used reagent in organic synthesis and is used to synthesize other organic compounds.
-It can be used as a stable ligand for aromatic hydrocarbon lithium or magnesium reagents for metal organic chemical reactions.
-It can also be used to catalyze coupling reactions, such as Suzuki coupling reactions and Suzuki-Miyaura cross-coupling reactions, to construct carbon-carbon bonds.
Preparation Method:
The preparation of (4-(1-(Methoxycarbonyl)cyclopropyl)-phenyl)boronic acid can be carried out by the following steps:
1. 1-Bromocyclopropane is reacted with methyl formate to obtain methyl (1-(methoxycarbonyl) cyclopropyl) formate.
2. The product obtained in step 1 is reacted with phenylboronic acid in acetonitrile or dimethylformamide to produce the target product.
Safety Information:
(4-(1-(Methoxycarbonyl)cyclopropyl)-phenyl) The safety information of boronic acid is limited, so the following safety measures should be followed when using it:
-It may be irritating to the eyes, skin and respiratory tract, so avoid contact, if contact occurs, rinse immediately with plenty of water.
-Follow good laboratory safety practices during handling and storage.
-Keep away from fire and heat sources and store in a dry, cool place.
-Wear appropriate protective gloves, glasses and protective clothing during use or handling. If ingested or inhaled, seek medical attention immediately.
Last Update：2024-04-10 22:29:15
